Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.051ng/mL |
Detection Limit: | 0.156-10ng/mL |
Short Description : | This PALLD Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Gene Symbol: | PALLD |
Gene ID: | 23022 |
Uniprot ID: | PALLD_HUMAN |
Sample Type: | tissue homogenates or other biological fluids. |
Tissue Specificity | Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6, HPAF, IMIM-PC2, SUIT-2 and PancTu-II sporadic pancreatic cancer cell lines. |
Post Translational Modifications | Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility. |
Function | Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci. |
Protein Name | Palladin Sih002 Sarcoma Antigen Ny-Sar-77 |
Database Links | |
Cellular Localisation | Cytoplasm Cytoskeleton Cell Junction Focal Adhesion Myofibril Sarcomere Z Line Cell Projection Ruffle Podosome Lamellipodium Axon Growth Cone Localizes To Stress Fibers And Z Lines Preferentially Expressed In The Excitatory Presynaptic Terminals |
Alternative ELISA Names | Palladin ELISA kit Sih002 ELISA kit Sarcoma Antigen Ny-Sar-77 ELISA kit PALLD ELISA kit KIAA0992 ELISA kit CGI-151 ELISA kit |
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Information sourced from Uniprot.org