| Host: |
E.coli |
| Applications: |
ELISA/Immunogen/SDS-PAGE/WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Recombinant-Human PAK6-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Formulation: |
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: |
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: |
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation. |
| Function | Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. |
| Protein Name | Serine/Threonine-Protein Kinase Pak 6Pak-5P21-Activated Kinase 6Pak-6 |
| Database Links | Reactome: R-HSA-428540Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013405Reactome: R-HSA-9013407Reactome: R-HSA-9013424 |
| Cellular Localisation | CytoplasmNucleusCotranslocates Into Nucleus With Ar In Response To Androgen Induction |
| Alternative Protein Names | Serine/Threonine-Protein Kinase Pak 6 proteinPak-5 proteinP21-Activated Kinase 6 proteinPak-6 proteinPAK6 proteinPAK5 protein |
Information sourced from Uniprot.org
