Human PAK6 protein (Recombinant) (N-His) (STJP009723)

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STJP009723
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PAK6-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PAK6
Gene ID: 106821730/56924
Uniprot ID: PAK6_HUMAN
Immunogen Region: Thr386-Cys681
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autophosphorylated. Phosphorylated by MAP2K6//MAPKK6, leading to PAK6 activation.
Function Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
Protein Name Serine/Threonine-Protein Kinase Pak 6
Pak-5
P21-Activated Kinase 6
Pak-6
Database Links Reactome: R-HSA-428540
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013405
Reactome: R-HSA-9013407
Reactome: R-HSA-9013424
Cellular Localisation Cytoplasm
Nucleus
Cotranslocates Into Nucleus With Ar In Response To Androgen Induction
Alternative Protein Names Serine/Threonine-Protein Kinase Pak 6 protein
Pak-5 protein
P21-Activated Kinase 6 protein
Pak-6 protein
PAK6 protein
PAK5 protein

Information sourced from Uniprot.org

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