| Post Translational Modifications | Four distinct glycoforms A, C, F and S arise from different N-linked oligosaccharide chains at amino acid residues Asn-46 and Asn-81. Glycodelin-A and -F are taken up by the cumulus cells in which partial deglycosylation takes place to produce glycodelin-C. |
| Function | Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa. |
| Protein Name | GlycodelinGdPlacental Protein 14Pp14Pregnancy-Associated Endometrial Alpha-2 GlobulinPaegPegProgestagen-Associated Endometrial ProteinProgesterone-Associated Endometrial ProteinZona-Binding Inhibitory Factor-1Zif-1 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Glycodelin proteinGd proteinPlacental Protein 14 proteinPp14 proteinPregnancy-Associated Endometrial Alpha-2 Globulin proteinPaeg proteinPeg proteinProgestagen-Associated Endometrial Protein proteinProgesterone-Associated Endometrial Protein proteinZona-Binding Inhibitory Factor-1 proteinZif-1 proteinPAEP protein |
Information sourced from Uniprot.org
