| Function | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production. Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Protein Name | Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - MitochondrialScot3-Oxoacid Coa-Transferase 1Somatic-Type Succinyl-Coa -3-Oxoacid Coa-TransferaseScot-SSuccinyl-Coa -3-Oxoacid Coa Transferase |
| Database Links | Reactome: R-HSA-77108Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - Mitochondrial proteinScot protein3-Oxoacid Coa-Transferase 1 proteinSomatic-Type Succinyl-Coa -3-Oxoacid Coa-Transferase proteinScot-S proteinSuccinyl-Coa -3-Oxoacid Coa Transferase proteinOXCT1 proteinOXCT proteinSCOT protein |
Information sourced from Uniprot.org
