Human OSGEP protein (Recombinant) (His-Tag) (STJP018889)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human OSGEP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSGEP |
| Gene ID | 55644 |
| Uniprot ID | OSGEP_HUMAN |
| Accession Number | NP_060277 |
| Immunogen | Human |
| Immunogen Region | 1-335aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMPAVLGF EGSANKIGVG VVRDGKVLAN PRRTYVTPPG TGFLPGDTAR HHRAVILDLL QEALTESGLT SQDIDCIAYT KGPGMGAPLV SVAVVARTVA QLWNKPLVGV NHCIGHIEMG RLITGATSPT VLYVSGGNTQ VIAYSEHRYR IFGETIDIAV GNCLDRFARV LKISNDPSPG YNIEQMAKRG KKLVELPYTV KGMDVSFS |
Additional Info
| Tissue Specificity | Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas. |
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. |
| Protein Name | Trna N6-Adenosine ThreonylcarbamoyltransferaseN6-L-Threonylcarbamoyladenine SynthaseT(6a SynthaseO-Sialoglycoprotein EndopeptidaseHosgepT(6a37 Threonylcarbamoyladenosine Biosynthesis Protein OsgepTrna Threonylcarbamoyladenosine Biosynthesis Protein Osgep |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Trna N6-Adenosine Threonylcarbamoyltransferase proteinN6-L-Threonylcarbamoyladenine Synthase proteinT(6a Synthase proteinO-Sialoglycoprotein Endopeptidase proteinHosgep proteinT(6a37 Threonylcarbamoyladenosine Biosynthesis Protein Osgep proteinTrna Threonylcarbamoyladenosine Biosynthesis Protein Osgep proteinOSGEP proteinGCPL1 protein |
Information sourced from Uniprot.org