| Post Translational Modifications | Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. Phosphorylation is induced by phorbol esters and decreases its half-time. |
| Function | Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and huntingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR).regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response. During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1. |
| Protein Name | OptineurinE3-14.7k-Interacting ProteinFip-2Huntingtin Yeast Partner LHuntingtin-Interacting Protein 7Hip-7Huntingtin-Interacting Protein LNemo-Related ProteinOptic Neuropathy-Inducing ProteinTranscription Factor Iiia-Interacting ProteinTfiiia-Intp |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-5205685Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-8854214Reactome: R-HSA-9013973Reactome: R-HSA-936964Reactome: R-HSA-9824878Reactome: R-HSA-9828211 |
| Cellular Localisation | CytoplasmPerinuclear RegionGolgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleAutophagosomeRecycling EndosomeFound In The Perinuclear Region And Associates With The Golgi ApparatusColocalizes With Myo6 And Rab8 At The Golgi Complex And In Vesicular Structures Close To The Plasma MembraneLocalizes To Lc3-Positive Cytoplasmic Vesicles Upon Induction Of Autophagy |
| Alternative Protein Names | Optineurin proteinE3-14.7k-Interacting Protein proteinFip-2 proteinHuntingtin Yeast Partner L proteinHuntingtin-Interacting Protein 7 proteinHip-7 proteinHuntingtin-Interacting Protein L proteinNemo-Related Protein proteinOptic Neuropathy-Inducing Protein proteinTranscription Factor Iiia-Interacting Protein proteinTfiiia-Intp proteinOPTN proteinFIP2 proteinGLC1E proteinHIP7 proteinHYPL proteinNRP protein |
Information sourced from Uniprot.org
