Human Oncostatin-M/OSM protein (Recombinant) (C-His&Avi) {Biotin} (STJP020203)

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STJP020203
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Biotin
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: OSM
Gene ID: 5008
Uniprot ID: ONCM_HUMAN
Immunogen Region: Ala26-Arg221
Immunogen: Biotinylated Recombinant Human Oncostatin-M/OSM Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Ala26-Arg221) of Human Oncostatin-M fused with a His tag and Avi tag at the C-terminal.
Post Translational Modifications Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
Function Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Protein Name Oncostatin-M
Osm
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-6788467
Cellular Localisation Secreted
Alternative Protein Names Oncostatin-M protein
Osm protein
OSM protein

Information sourced from Uniprot.org

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