| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human OGG1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | OGG1 |
| Gene ID: | 4968 |
| Uniprot ID: | OGG1_HUMAN |
| Immunogen Region: | Ser31-Gly345 |
| Immunogen: | Homo sapiens (Human) |
| Function | DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. |
| Protein Name | N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site LyaseAp Lyase |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-110357Reactome: R-HSA-5649702Reactome: R-HSA-9656255Reactome: R-HSA-9656256Reactome: R-HSA-9657050 O15527-4 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpeckleNucleus MatrixTogether With Apex1 Is Recruited To Nuclear Speckles In Uva-Irradiated CellsIsoform 1a: NucleusIsoform 2a: Mitochondrion |
| Alternative Protein Names | N-Glycosylase/Dna Lyase Includes - 8-Oxoguanine Dna Glycosylase - Dna-(Apurinic Or Apyrimidinic Site Lyase proteinAp Lyase proteinOGG1 proteinMMH proteinMUTM proteinOGH1 protein |
Information sourced from Uniprot.org