SDS-PAGE gel of recombinant human NUDT16L1 SDOS protein under reducing conditions Coomassie blue stained

Human NUDT16L1/SDOS protein (Recombinant) (His-Tag) (STJP017071)

SKU:
STJP017071
£158.50 - £965.50
Free Shipping
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Short Description :Recombinant-Human NUDT16L1/SDOS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:NUDT16L1
Gene ID:84309
Uniprot ID:TIRR_HUMAN
Accession Number:NP_115725
Immunogen:Human
Immunogen Region:1-211aa
Immunogen Sequence: MSTAAVPELK QISRVEAMRL GPGWSHSCHA MLYAANPGQL FGRIPMRFSV LMQMRFDGLL GFPGGFVDRR FWSLEDGLNR VLGLGLGCLR LTEADYLSSH LTEGPHRVVA HLYARQLTLE QLHAVEISAV HSRDHGLEVL GLVRVPLYTQ KDRVGGFPNF LSNAFVSTAK CQLLFALKVL NMMPEEKLVE ALAAATEKQK KALEKL
Function Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA.
Protein Name Tudor-Interacting Repair Regulator Protein
Nudt16-Like Protein 1
Protein Syndesmos
Database Links
Cellular Localisation Nucleus
Alternative Protein Names Tudor-Interacting Repair Regulator Protein protein
Nudt16-Like Protein 1 protein
Protein Syndesmos protein
NUDT16L1 protein
SDOS protein
TIRR protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP019690 Human IRF2 protein (Recombinant) (His-Tag) (STJP019690) E.coli SDS-PAGE
STJP017768 Human CSTF1 protein (Recombinant) (His-Tag) (STJP017768) E.coli SDS-PAGE/Denatured
STJP017869 Human RNF4 protein (Recombinant) (His-Tag) (STJP017869) E.coli SDS-PAGE
STJP017870 Human NDUFA5 protein (Recombinant) (His-Tag) (STJP017870) E.coli SDS-PAGE
STJP017883 Human NDUFAF1 protein (Recombinant) (His-Tag) (STJP017883) E.coli SDS-PAGE

Related Products

!