| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human NRL-N-His-KSI protein was developed from e.coli and has a target region of N-His-KSI. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for further information. |
| Gene Symbol: | NRL |
| Gene ID: | 4901 |
| Uniprot ID: | NRL_HUMAN |
| Immunogen Region: | Ala2-Leu237 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylated. Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation. |
| Function | Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner. |
| Protein Name | Neural Retina-Specific Leucine Zipper ProteinNrl |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Neural Retina-Specific Leucine Zipper Protein proteinNrl proteinNRL proteinD14S46E protein |
Information sourced from Uniprot.org