| Function | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes.not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Protein Name | Neuronal Cell Adhesion MoleculeNr-CamNeuronal Surface Protein BravoHbravoNgcam-Related Cell Adhesion MoleculeNg-Cam-Related |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-447038Reactome: R-HSA-447043 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonSecretedDetected At Nodes Of Ranvier |
| Alternative Protein Names | Neuronal Cell Adhesion Molecule proteinNr-Cam proteinNeuronal Surface Protein Bravo proteinHbravo proteinNgcam-Related Cell Adhesion Molecule proteinNg-Cam-Related proteinNRCAM proteinKIAA0343 protein |
Information sourced from Uniprot.org
