| Function | Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. |
| Protein Name | Nuclear Receptor Subfamily 2 Group C Member 2Orphan Nuclear Receptor Tak1Orphan Nuclear Receptor Tr4Testicular Receptor 4 |
| Database Links | Reactome: R-HSA-383280 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Nuclear Receptor Subfamily 2 Group C Member 2 proteinOrphan Nuclear Receptor Tak1 proteinOrphan Nuclear Receptor Tr4 proteinTesticular Receptor 4 proteinNR2C2 proteinTAK1 proteinTR4 protein |
Information sourced from Uniprot.org
