| Post Translational Modifications | Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation. |
| Function | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis. Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. |
| Protein Name | Oxysterols Receptor Lxr-BetaLiver X Receptor BetaNuclear Receptor NerNuclear Receptor Subfamily 1 Group H Member 2Ubiquitously-Expressed Nuclear Receptor |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-383280Reactome: R-HSA-4090294Reactome: R-HSA-8866427Reactome: R-HSA-9029558Reactome: R-HSA-9029569Reactome: R-HSA-9031525Reactome: R-HSA-9031528Reactome: R-HSA-9623433 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Oxysterols Receptor Lxr-Beta proteinLiver X Receptor Beta proteinNuclear Receptor Ner proteinNuclear Receptor Subfamily 1 Group H Member 2 proteinUbiquitously-Expressed Nuclear Receptor proteinNR1H2 proteinLXRB proteinNER proteinUNR protein |
Information sourced from Uniprot.org
