Human NPHS1 protein (Recombinant) (N-His) (STJP003316)

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STJP003316
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NPHS1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NPHS1
Gene ID: 4868
Uniprot ID: NPHN_HUMAN
Immunogen Region: Pro89-Trp374
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated at Tyr-1193 by FYN, leading to the recruitment and activation of phospholipase C-gamma-1/PLCG1. Tyrosine phosphorylation is reduced by high glucose levels. Dephosphorylated by tensin TNS2 which leads to reduced binding of NPHN1 to PIK3R1.
Function Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Protein Name Nephrin
Renal Glomerulus-Specific Cell Adhesion Receptor
Database Links Reactome: R-HSA-373753
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Predominantly Located At Podocyte Slit Diaphragm Between Podocyte Foot Processes
Also Associated With Podocyte Apical Plasma Membrane
Alternative Protein Names Nephrin protein
Renal Glomerulus-Specific Cell Adhesion Receptor protein
NPHS1 protein
NPHN protein

Information sourced from Uniprot.org

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