Human NPC1 protein (Recombinant) (N-His) (STJP003217)

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STJP003217
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NPC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NPC1
Gene ID: 4864
Uniprot ID: NPC1_HUMAN
Immunogen Region: Gln23-Asp266
Immunogen: Homo sapiens (Human)
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Protein Name Npc Intracellular Cholesterol Transporter 1
Niemann-Pick C1 Protein
Database Links Reactome: R-HSA-8964038
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Alternative Protein Names Npc Intracellular Cholesterol Transporter 1 protein
Niemann-Pick C1 Protein protein
NPC1 protein

Information sourced from Uniprot.org

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