| Post Translational Modifications | Isoform v2: Phosphorylation at Ser-475 by CaMK2 and at Ser-490, Thr-494 and Ser-498 by PKC/PRKCA positively regulates its catalytic activity. Isoform v2: S-nitrosylation in response to nitric oxide inhibits its catalytic activity. |
| Function | Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. May play a role in cell growth and apoptosis. Isoform v2: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contributes to endothelial response to thrombin. Regulates redox-dependent processes in lymphocytes and spermatozoa. Isoform v1: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Isoform v5: This isoform lacks calcium-binding domains and was showed to present a NADPH oxidase activity in a calcium-independent manner. May be involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. However another study showed an absence of oxidase activity. Subject to rapid degradation. Isoform v3: Lacks calcium-dependent NADPH oxidase activity. Isoform v4: Lacks calcium-dependent NADPH oxidase activity. |
| Protein Name | Nadph Oxidase 5 |
| Database Links | Reactome: R-HSA-3299685 |
| Cellular Localisation | Isoform V2: Endoplasmic ReticulumCell MembraneMulti-Pass Membrane ProteinCalcium-Sensitive Association And Dissociation Between The N- And C-Terminal Domains Appears To Facilitate Its Localization To The Cell MembraneIsoform V5: Endoplasmic Reticulum |
| Alternative Protein Names | Nadph Oxidase 5 proteinNOX5 protein |
Information sourced from Uniprot.org
