Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017407)

Human NOTCH2NL (Notch2 N-Terminal Like Protein) Sandwich ELISA Kit Ready-To-Use Kit (STJE0017407)

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STJE0017407
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Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description : This NOTCH2NL Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NOTCH2NLA
Gene ID: 388677
Uniprot ID: NT2NA_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Widely expressed with higher levels in leukocytes and lymph nodes. Expressed in radial glia neural stem cells during cortical development.
Post Translational Modifications Cleaved by ELANE.
Function Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation.
Protein Name Notch Homolog 2 N-Terminal-Like Protein A
Notch Homolog 2 N-Terminal-Like Protein
Database Links
Cellular Localisation Secreted
Cytoplasm
Alternative ELISA Names Notch Homolog 2 N-Terminal-Like Protein A ELISA kit
Notch Homolog 2 N-Terminal-Like Protein ELISA kit
NOTCH2NLA ELISA kit
N2N ELISA kit
NOTCH2NL ELISA kit
output

Information sourced from Uniprot.org

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