| Function | Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12. Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis. Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species. Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner. In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases. |
| Protein Name | Nlr Family Member X1Caterpiller Protein 11.3Clr11.3Nucleotide-Binding Oligomerization Domain Protein 5Nucleotide-Binding Oligomerization Domain Protein 9 |
| Database Links | Reactome: R-HSA-168928Reactome: R-HSA-936440Reactome: R-HSA-9758274 |
| Cellular Localisation | Mitochondrion Outer Membrane |
| Alternative Protein Names | Nlr Family Member X1 proteinCaterpiller Protein 11.3 proteinClr11.3 proteinNucleotide-Binding Oligomerization Domain Protein 5 proteinNucleotide-Binding Oligomerization Domain Protein 9 proteinNLRX1 proteinNOD5 proteinNOD9 protein |
Information sourced from Uniprot.org
