| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | NCR1 |
| Gene ID: | 9437 |
| Uniprot ID: | NCTR1_HUMAN |
| Immunogen Region: | Gln22-Asn255 |
| Immunogen: | Recombinant Human NKp46/NCR1/CD335 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-Asn255) of Human NKp46/NCR1/CD335 (Accession #O76036-1) fused with a C-mFc tag at the C-terminus. |
| Immunogen Sequence: | QQQTLPKPFIWAEPHFMVPK EKQVTICCQGNYGAVEYQLH FEGSLFAVDRPKPPERINKV KFYIPDMNSRMAGQYSCIYR VGELWSEPSNLLDLVVTEMY DTPTLSVHPGPEVISGEKVT FYCRLDTATSMFLLLKEGRS SHVQRGYGKVQAEFPLGPVT TAHRGTYRCFGSYNNHAWSF PSEPVKLLVTGDIENTSLAP EDPTFPADTWGTYLLTTETG LQKDHALWDHTAQN |
| Tissue Specificity | Selectively expressed by both resting and activated NK cells. |
| Post Translational Modifications | N-glycosylated. O-glycosylated. |
| Function | Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 1Lymphocyte Antigen 94 HomologNk Cell-Activating ReceptorNatural Killer Cell P46-Related ProteinNk-P46Nkp46Hnkp46Cd Antigen Cd335 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Natural Cytotoxicity Triggering Receptor 1 proteinLymphocyte Antigen 94 Homolog proteinNk Cell-Activating Receptor proteinNatural Killer Cell P46-Related Protein proteinNk-P46 proteinNkp46 proteinHnkp46 proteinCd Antigen Cd335 proteinNCR1 proteinLY94 protein |
Information sourced from Uniprot.org