| Tissue Specificity | Expressed in NK cell subsets, in particular in adaptive CD57-positive NK cells (at protein level). Expressed in terminally differentiated cytotoxic gamma-delta T cells (at protein level). Expressed in alpha-beta T cells subsets (at protein level). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed within NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level). |
| Function | Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy. Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection. Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation. |
| Protein Name | Nkg2-C Type Ii Integral Membrane ProteinCd159 Antigen-Like Family Member CNk Cell Receptor CNkg2-C-Activating Nk ReceptorCd Antigen Cd159c |
| Database Links | Reactome: R-HSA-2172127Reactome: R-HSA-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Nkg2-C Type Ii Integral Membrane Protein proteinCd159 Antigen-Like Family Member C proteinNk Cell Receptor C proteinNkg2-C-Activating Nk Receptor proteinCd Antigen Cd159c proteinKLRC2 proteinNKG2C protein |
Information sourced from Uniprot.org
