| Tissue Specificity | Kidney and intestine. |
| Post Translational Modifications | O-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1. Phosphorylation at Thr-779 increases SLC9A1 activity. Specifically dephosphorylated at Thr-779 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-648 by AKT1 reduces SLC9A1 binding to CALM1. Palmitoylated.may play a major role in SLC9A1 regulation. |
| Function | Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs. |
| Protein Name | Sodium/Hydrogen Exchanger 1ApnhNa(+/H(+ Antiporter - Amiloride-SensitiveNa(+/H(+ Exchanger 1Nhe-1Solute Carrier Family 9 Member 1 |
| Database Links | Reactome: R-HSA-2160916Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneLocalized Basolaterally In Every Epithelial CellExcept In The Choroid Plexus Where Slc9a1 Is Expressed Luminally |
| Alternative ELISA Names | Sodium/Hydrogen Exchanger 1 ELISA kitApnh ELISA kitNa(+/H(+ Antiporter - Amiloride-Sensitive ELISA kitNa(+/H(+ Exchanger 1 ELISA kitNhe-1 ELISA kitSolute Carrier Family 9 Member 1 ELISA kitSLC9A1 ELISA kitAPNH1 ELISA kitNHE1 ELISA kit |
| output | |
Information sourced from Uniprot.org
