| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 4.2 pg/mL |
| Detection Limit: | 156-1000 pg/ml |
| Conjugation: | Biotin |
| Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
| Assay Time: | 4 hours |
| Detection: | Colorimetric |
| Gene Symbol: | NGF |
| Gene ID: | 4803 |
| Uniprot ID: | NGF_HUMAN |
| Sample Type: | serum, plasma and cell culture supernates |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form. |
| Protein Name | Beta-Nerve Growth Factor Beta-Ngf |
| Database Links | Reactome: R-HSA-167021 Reactome: R-HSA-167044 Reactome: R-HSA-167060 Reactome: R-HSA-170968 Reactome: R-HSA-170984 Reactome: R-HSA-177504 Reactome: R-HSA-187042 Reactome: R-HSA-187706 Reactome: R-HSA-193648 Reactome: R-HSA-193670 Reactome: R-HSA-193681 Reactome: R-HSA-198203 Reactome: R-HSA-198745 Reactome: R-HSA-205017 Reactome: R-HSA-205025 Reactome: R-HSA-205043 Reactome: R-HSA-209543 Reactome: R-HSA-209560 Reactome: R-HSA-209563 |
| Cellular Localisation | Secreted Endosome Lumen Prongf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr |
| Alternative ELISA Names | Beta-Nerve Growth Factor ELISA kit Beta-Ngf ELISA kit NGF ELISA kit NGFB ELISA kit |
| output |
Information sourced from Uniprot.org
