Human NFKBIB protein (Recombinant) (N-His) (STJP005463)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human NFKBIB-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | NFKBIB |
| Gene ID | 4793 |
| Uniprot ID | IKBB_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu85-His332 |
Additional Info
| Post Translational Modifications | Phosphorylated by RPS6KA1.followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. |
| Function | Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. |
| Protein Name | Nf-Kappa-B Inhibitor BetaNf-Kappa-BibI-Kappa-B-BetaIkb-BIkb-BetaIkappabbetaThyroid Receptor-Interacting Protein 9Tr-Interacting Protein 9Trip-9 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1810476Reactome: R-HSA-445989Reactome: R-HSA-933542 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Nf-Kappa-B Inhibitor Beta proteinNf-Kappa-Bib proteinI-Kappa-B-Beta proteinIkb-B proteinIkb-Beta proteinIkappabbeta proteinThyroid Receptor-Interacting Protein 9 proteinTr-Interacting Protein 9 proteinTrip-9 proteinNFKBIB proteinIKBB proteinTRIP9 protein |
Information sourced from Uniprot.org