Human Neuroligin-3 protein (Recombinant) (STJP001854)

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STJP001854
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Neuroligin-3-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Gene Symbol: NLGN3
Gene ID: 54413
Uniprot ID: NLGN3_HUMAN
Immunogen Region: GLN38-SER689
Immunogen: Optimized DNA sequence encoding I extracellular domain of Human Neuroligin-3 (NL3 ) (GLN38-SER689 ) including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Expressed in the blood vessel walls (at protein level). Detected in throughout the brain and in spinal cord. Detected in brain, and at lower levels in pancreas islet beta cells.
Function Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
Protein Name Neuroligin-3
Gliotactin Homolog
Database Links Reactome: R-HSA-6794361
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Synapse
Detected At Both Glutamatergic And Gabaergic Synapses
Alternative Protein Names Neuroligin-3 protein
Gliotactin Homolog protein
NLGN3 protein
KIAA1480 protein
NL3 protein

Information sourced from Uniprot.org

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