| Post Translational Modifications | Isoform 2: N-glycosylated. |
| Function | Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose. |
| Protein Name | Sialidase-4N-Acetyl-Alpha-Neuraminidase 4 |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840310 Q8WWR8-2 |
| Cellular Localisation | Isoform 1: Cell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneMicrosome MembraneMitochondrion MembraneCell ProjectionNeuron ProjectionPredominantly Associates With Endoplasmic Reticulum MembranesOnly A Small Fraction Associates With Mitochondrial And Plasma MembranesIsoform 2: Mitochondrion Inner MembraneMitochondrion Outer MembraneLysosome LumenIsoform 2 Is SolubleN-Glycosylated And Found In The Lumen Of LysosomesHoweverNo Signal Sequence Nor N-Glycosylation Site Is Predicted From The Sequence |
| Alternative Protein Names | Sialidase-4 proteinN-Acetyl-Alpha-Neuraminidase 4 proteinNEU4 proteinLP5125 protein |
Information sourced from Uniprot.org
