| Tissue Specificity | Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast. |
| Post Translational Modifications | |
| Function | Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance. |
| Protein Name | NeudesinCell Immortalization-Related Protein 2Neuron-Derived Neurotrophic FactorProtein Gig47Secreted Protein Of Unknown FunctionSpuf Protein |
| Database Links | |
| Cellular Localisation | SecretedExtracellular SpaceMitochondrionEndoplasmic ReticulumLocalized To Mitochondria And Endoplasmic Reticulum By Pink1 And Park7 |
| Alternative ELISA Names | Neudesin ELISA kitCell Immortalization-Related Protein 2 ELISA kitNeuron-Derived Neurotrophic Factor ELISA kitProtein Gig47 ELISA kitSecreted Protein Of Unknown Function ELISA kitSpuf Protein ELISA kitNENF ELISA kitCIR2 ELISA kitSPUF ELISA kit |
| output | |
Information sourced from Uniprot.org
