Human NECTIN4/PVRL4 protein (Recombinant-Active) (C-His) (STJP012736)

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STJP012736-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human NECTIN4/PVRL4-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 8% Sucrose, 0.05% Tween 80, pH 8.0.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: NECTIN4
Gene ID: 81607
Uniprot ID: NECT4_HUMAN
Immunogen Region: Gly32-Val351
Immunogen: Homo sapiens (Human)
Post Translational Modifications The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Function Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.
Protein Name Nectin-4
Ig Superfamily Receptor Lnir
Nectin Cell Adhesion Molecule 4
Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Colocalizes With Afdn At Cadherin-Based Adherens Junctions
Processed Poliovirus Receptor-Related Protein 4: Secreted
The Secreted Form Is Found In Breast Tumor Patients
Alternative Protein Names Nectin-4 protein
Ig Superfamily Receptor Lnir protein
Nectin Cell Adhesion Molecule 4 protein
Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 protein
NECTIN4 protein
LNIR protein
PRR4 protein
PVRL4 protein

Information sourced from Uniprot.org

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