Biotinylated Human Nectin-4 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Human Nectin-4 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001629)

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STJP001629
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Nectin-4-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: NECTIN4
Gene ID: 81607
Uniprot ID: NECT4_HUMAN
Immunogen Region: Gly32-Val351
Immunogen: DNA sequence encoding Human Nectin-4 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
Function Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. (Microbial infection) Acts as a receptor for measles virus.
Protein Name Nectin-4
Ig Superfamily Receptor Lnir
Nectin Cell Adhesion Molecule 4
Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Colocalizes With Afdn At Cadherin-Based Adherens Junctions
Processed Poliovirus Receptor-Related Protein 4: Secreted
The Secreted Form Is Found In Breast Tumor Patients
Alternative Protein Names Nectin-4 protein
Ig Superfamily Receptor Lnir protein
Nectin Cell Adhesion Molecule 4 protein
Poliovirus Receptor-Related Protein 4 Cleaved Into - Processed Poliovirus Receptor-Related Protein 4 protein
NECTIN4 protein
LNIR protein
PRR4 protein
PVRL4 protein

Information sourced from Uniprot.org

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