Human Nectin-2/PVRL2/CD112 protein (Recombinant) (C-hFc) (STJP019868)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Leu360) of Human Nectin-2/PVRL2/CD112 (Accession #Q92692-2) fused with a C-hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human Nectin-2/PVRL2/CD112-C-hFc protein was developed in hek293 cells using the region Gln32-Leu360. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | NECTIN2 |
| Gene ID | 5819 |
| Uniprot ID | NECT2_HUMAN |
| Immunogen | Recombinant Human Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Leu360) of Human Nectin-2/PVRL2/CD112 (Accession #Q92692-2) fused with a C-hFc tag at the C-terminus. |
| Immunogen Region | Gln32-Leu360 |
| Immunogen Sequence | QDVRVQVLPEVRGQLGGTVE LPCHLLPPVPGLYISLVTWQ RPDAPANHQNVAAFHPKMGP SFPSPKPGSERLSFVSAKQS TGQDTEAELQDATLALHGLT VEDEGNYTCEFATFPKGSVR GMTWLRVIAKPKNQAEAQKV TFSQDPTTVALCISKEGRPP ARISWLSSLDWEAKETQVSG TLAGTVTVTSRFTLVPSGRA DGVTVTCKVEHESFEEPALI PVTLSVRYPPEVSISGYDD |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebNectin Cell Adhesion Molecule 2Poliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nectin-2 proteinHerpes Virus Entry Mediator B proteinHerpesvirus Entry Mediator B proteinHveb proteinNectin Cell Adhesion Molecule 2 proteinPoliovirus Receptor-Related Protein 2 proteinCd Antigen Cd112 proteinNECTIN2 proteinHVEB proteinPRR2 proteinPVRL2 protein |
Information sourced from Uniprot.org