| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human Nectin-1 3 Mu g/mL (100 Mu L/well) can bind Recombinant Human Nectin-3 with a linear range of 180-720 ng/mL. |
| Gene Symbol: |
NECTIN1 |
| Gene ID: |
5818 |
| Uniprot ID: |
NECT1_HUMAN |
| Immunogen Region: |
Met1-Thr334 |
| Immunogen: |
Recombinant Human Nectin-1/PVRL1/CD111 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Thr334) of human Nectin-1/PVRL1/CD111 (Accession #NP_002846.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: |
MARMGLAGAAGRWWGLALGL TAFFLPGVHSQVVQVNDSMY GFIGTDVVLHCSFANPLPSV KITQVTWQKSTNGSKQNVAI YNPSMGVSVLAPYRERVEFL RPSFTDGTIRLSRLELEDEG VYICEFATFPTGNRESQLNL TVMAKPTNWIEGTQAVLRAK KGQDDKVLVATCTSANGKPP SVVSWETRLKGEAEYQEIRN PNGTVTVISRYRLVPSREAH QQSLACIVNYHMDRFKESL |
| Function | Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Involved in synaptogegesis. Has some neurite outgrowth-promoting activity. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Required for enamel mineralization. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells. |
| Protein Name | Nectin-1Herpes Virus Entry Mediator CHerpesvirus Entry Mediator CHvecHerpesvirus Ig-Like ReceptorHigrNectin Cell Adhesion Molecule 1Poliovirus Receptor-Related Protein 1Cd Antigen Cd111 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionPresynaptic Cell MembraneIn The Auditory EpitheliumSpecificaly Localizes To The Apical Side Of The Lateral Membranes Of Hair CellsIsoform Alpha: Cell MembraneIsoform Delta: Cell MembraneIsoform Gamma: Secreted |
| Alternative Protein Names | Nectin-1 proteinHerpes Virus Entry Mediator C proteinHerpesvirus Entry Mediator C proteinHvec proteinHerpesvirus Ig-Like Receptor proteinHigr proteinNectin Cell Adhesion Molecule 1 proteinPoliovirus Receptor-Related Protein 1 proteinCd Antigen Cd111 proteinNECTIN1 proteinHVEC proteinPRR1 proteinPVRL1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
