| Post Translational Modifications | (Microbial infection) Ubiquitinated by CBL following infection by herpes simplex virus 1/HHV-1 and association with HHV-1 envelope glycoprotein D, leading to its removal from cell surface. |
| Function | Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Involved in synaptogegesis. Has some neurite outgrowth-promoting activity. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Required for enamel mineralization. (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells. |
| Protein Name | Nectin-1Herpes Virus Entry Mediator CHerpesvirus Entry Mediator CHvecHerpesvirus Ig-Like ReceptorHigrNectin Cell Adhesion Molecule 1Poliovirus Receptor-Related Protein 1Cd Antigen Cd111 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionPresynaptic Cell MembraneIn The Auditory EpitheliumSpecificaly Localizes To The Apical Side Of The Lateral Membranes Of Hair CellsIsoform Alpha: Cell MembraneIsoform Delta: Cell MembraneIsoform Gamma: Secreted |
| Alternative Protein Names | Nectin-1 proteinHerpes Virus Entry Mediator C proteinHerpesvirus Entry Mediator C proteinHvec proteinHerpesvirus Ig-Like Receptor proteinHigr proteinNectin Cell Adhesion Molecule 1 proteinPoliovirus Receptor-Related Protein 1 proteinCd Antigen Cd111 proteinNECTIN1 proteinHVEC proteinPRR1 proteinPVRL1 protein |
Information sourced from Uniprot.org
