Tissue Specificity | Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues.absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level). |
Post Translational Modifications | |
Function | Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. |
Protein Name | Protein Ndrg2N-Myc Downstream-Regulated Gene 2 ProteinProtein Syld709613 |
Database Links | |
Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionGrowth ConeIn NeuronsSeems To Concentrate At Axonal Growth ConePerinuclear In Neurons |
Alternative ELISA Names | Protein Ndrg2 ELISA kitN-Myc Downstream-Regulated Gene 2 Protein ELISA kitProtein Syld709613 ELISA kitNDRG2 ELISA kitKIAA1248 ELISA kitSYLD ELISA kit |
output | |
Information sourced from Uniprot.org