| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules. |
| Protein Name | Kinetochore Protein Ndc80 HomologHighly Expressed In Cancer ProteinKinetochore Protein Hec1Hshec1Kinetochore-Associated Protein 2Retinoblastoma-Associated Protein Hec |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Kinetochores From Late Prophase To AnaphaseLocalizes Specifically To The Outer Plate Of The Kinetochore |
| Alternative Protein Names | Kinetochore Protein Ndc80 Homolog proteinHighly Expressed In Cancer Protein proteinKinetochore Protein Hec1 proteinHshec1 proteinKinetochore-Associated Protein 2 proteinRetinoblastoma-Associated Protein Hec proteinNDC80 proteinHEC proteinHEC1 proteinKNTC2 protein |
Information sourced from Uniprot.org
