Human NCR3/NKp30/CD337 protein (Recombinant) (C-hFc & His) (STJP002593)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human NCR3/NKp30/CD337 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu19-Thr138) of human NCR3/NKp300 (Accession #NP_001138938.1) fused with an Fc, 6×His tag at the C-terminus.
General Information
| Short Description | Recombinant-Human NCR3/NKp30/CD337-C-hFc & His protein was developed in hek293 cells using the region Leu19-Thr138. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Measured by its binding ability in a functional ELISA. Immobilized recombinant Human B7-H6 at 2 Mu g/mL (100 Mu L/well) can bind recombinant Human NCR3, the EC50 of Human NCR3 is 66.43 ng/mL. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | NCR3 |
| Gene ID | 259197 |
| Uniprot ID | NCTR3_HUMAN |
| Immunogen | Recombinant Human NCR3/NKp30/CD337 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu19-Thr138) of human NCR3/NKp300 (Accession #NP_001138938.1) fused with an Fc, 6×His tag at the C-terminus. |
| Immunogen Region | Leu19-Thr138 |
| Immunogen Sequence | LWVSQPPEIRTLEGSSAFLP CSFNASQGRLAIGSVTWFRD EVVPGKEVRNGTPEFRGRLA PLASSRFLHDHQAELHIRDV RGHDASIYVCRVEVLGLGVG TGNGTRLVVEKEHPQLGAGT |
Additional Info
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Protein Name | Natural Cytotoxicity Triggering Receptor 3Activating Natural Killer Receptor P30Natural Killer Cell P30-Related ProteinNk-P30Nkp30Cd Antigen Cd337 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Natural Cytotoxicity Triggering Receptor 3 proteinActivating Natural Killer Receptor P30 proteinNatural Killer Cell P30-Related Protein proteinNk-P30 proteinNkp30 proteinCd Antigen Cd337 proteinNCR3 protein1C7 proteinLY117 protein |
Information sourced from Uniprot.org