Human NCAPH protein (Recombinant) (N-GST & C-His) (STJP009047)

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STJP009047
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human NCAPH-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NCAPH
Gene ID: 23397
Uniprot ID: CND2_HUMAN
Immunogen Region: Glu471-Pro526
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation.
Function Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
Protein Name Condensin Complex Subunit 2
Barren Homolog Protein 1
Chromosome-Associated Protein H
Hcap-H
Non-Smc Condensin I Complex Subunit H
Xcap-H Homolog
Database Links Reactome: R-HSA-2514853
Cellular Localisation Nucleus
Cytoplasm
Chromosome
In Interphase Cells
The Majority Of The Condensin Complex Is Found In The Cytoplasm
While A Minority Of The Complex Is Associated With Chromatin
A Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase Cells
During Mitosis
Most Of The Condensin Complex Is Associated With The Chromatin
At The Onset Of Prophase
The Regulatory Subunits Of The Complex Are Phosphorylated By Cdk1
Leading To Condensin's Association With Chromosome Arms And To Chromosome Condensation
Dissociation From Chromosomes Is Observed In Late Telophase
Alternative Protein Names Condensin Complex Subunit 2 protein
Barren Homolog Protein 1 protein
Chromosome-Associated Protein H protein
Hcap-H protein
Non-Smc Condensin I Complex Subunit H protein
Xcap-H Homolog protein
NCAPH protein
BRRN protein
BRRN1 protein
CAPH protein
KIAA0074 protein

Information sourced from Uniprot.org