| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.01 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by the ability of the immobilized protein to support the adhesion of Neuro‑2A Human neuroblastoma cells. The ED50 for this effect is 1.8-7.2 Mu g/mL. |
| Gene Symbol: | NCAM1 |
| Gene ID: | 4684 |
| Uniprot ID: | NCAM1_HUMAN |
| Immunogen Region: | Leu20-Gly718 |
| Immunogen: | Recombinant Human NCAM-1/CD56 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Gly718) of Human NCAM-1/CD56 (Accession #NP_851996.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | LQVDIVPSQGEISVGESKFF LCQVAGDAKDKDISWFSPNG EKLTPNQQRISVVWNDDSSS TLTIYNANIDDAGIYKCVVT GEDGSESEATVNVKIFQKLM FKNAPTPQEFREGEDAVIVC DVVSSLPPTIIWKHKGRDVI LKKDVRFIVLSNNYLQIRGI KKTDEGTYRCEGRILARGEI NFKDIQVIVNVPPTIQARQN IVNATANLGQSVTLVCDAEG FPEPTMSWTKDGEQIEQEE |
| Function | This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabies virus. (Microbial infection) Acts as a receptor for Zika virus. |
| Protein Name | Neural Cell Adhesion Molecule 1N-Cam-1Ncam-1Cd Antigen Cd56 |
| Database Links | Reactome: R-HSA-3000178Reactome: R-HSA-375165Reactome: R-HSA-419037Reactome: R-HSA-445144Reactome: R-HSA-5673001Reactome: R-HSA-877300 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneIsoform 3: Cell MembraneLipid-AnchorGpi-AnchorIsoform 4: Cell MembraneIsoform 5: SecretedIsoform 6: Secreted |
| Alternative Protein Names | Neural Cell Adhesion Molecule 1 proteinN-Cam-1 proteinNcam-1 proteinCd Antigen Cd56 proteinNCAM1 proteinNCAM protein |
Information sourced from Uniprot.org
