| Function | N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo. Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity. Does not influence the acetyltransferase activity of NAA10. However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides. Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10. |
| Protein Name | N-Alpha-Acetyltransferase 50Hnaa50pN-Acetyltransferase 13N-Acetyltransferase 5Hnat5N-Acetyltransferase San HomologHsanN-Epsilon-Acetyltransferase 50Nate Catalytic Subunit |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusLocalizes To The Cytoplasm In Interphase Cells |
| Alternative Protein Names | N-Alpha-Acetyltransferase 50 proteinHnaa50p proteinN-Acetyltransferase 13 proteinN-Acetyltransferase 5 proteinHnat5 proteinN-Acetyltransferase San Homolog proteinHsan proteinN-Epsilon-Acetyltransferase 50 proteinNate Catalytic Subunit proteinNAA50 proteinMAK3 proteinNAT13 proteinNAT5 protein |
Information sourced from Uniprot.org
