Human NACA protein (Recombinant) (His-Tag) (STJP017410)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human NACA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.15M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NACA |
| Gene ID | 4666 |
| Uniprot ID | NACA_HUMAN |
| Accession Number | NP_001106672.1 |
| Immunogen | Human |
| Immunogen Region | 1-215aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation. Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. |
| Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. |
| Protein Name | Nascent Polypeptide-Associated Complex Subunit AlphaNac-AlphaAlpha-NacAllergen Hom S 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusThe Heterodimer Is Located Mainly In The CytosolAnd The Homodimer In The Nucleus |
| Alternative Protein Names | Nascent Polypeptide-Associated Complex Subunit Alpha proteinNac-Alpha proteinAlpha-Nac proteinAllergen Hom S 2 proteinNACA proteinHSD48 protein |
Information sourced from Uniprot.org