Name: Human N-RAS protein (Recombinant) (No-Tag) (STJP016633)
SKU: STJP016633
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Citations
Product Review

Host:	E.coli
Applications:	SDS-PAGE
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description :	Recombinant-Human N-RAS-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.

Formulation:	Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 100mM NaCl, 10% Glycerol
Concentration:	1 mg/mL
Storage Instruction:	For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.

Gene Symbol:	NRAS
Gene ID:	4893
Uniprot ID:	RASN_HUMAN
Immunogen Region:	1-186aa
Accession Number:	NP_002515
Immunogen:	Human
Immunogen Sequence:	MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ GVEDAFYTLV REIRQYRMKK LNSSDDGTQG CMGLPC

Post Translational Modifications	Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi. Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). Fatty-acylated at Lys-169 and/or Lys-170. Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors. (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL.
Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
Protein Name	Gtpase Nras Transforming Protein N-Ras
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6798695 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Golgi Apparatus Membrane Shuttles Between The Plasma Membrane And The Golgi Apparatus
Alternative Protein Names	Gtpase Nras protein Transforming Protein N-Ras protein NRAS protein HRAS1 protein

Information sourced from Uniprot.org

View product citations for antibody STJP016633 on CiteAb

Model	Name	Host	Application
STJP018169	Human K-Ras protein (Recombinant) (His-Tag) (STJP018169)	E.coli	SDS-PAGE
STJP016657	Human H-Ras protein (Recombinant) (His-Tag) (STJP016657)	E.coli	SDS-PAGE
STJP016749	Human K-Ras protein (Recombinant) (His-Tag) (STJP016749)	E.coli	SDS-PAGE
STJP007235	Human FGF19 protein (Recombinant) (N-His tag) (STJP007235)	E.coli	ELISA/Immunogen/SDS-PAGE/WB
STJP014334	Human KRAS/K-Ras 2 protein (Recombinant) (N-His) (STJP014334)	E.coli	ELISA/WB

Human N-RAS protein (Recombinant) (No-Tag) (STJP016633)

General Information

Product Properties

Target Information

Additional Info

Citations

Product Review

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