Human Myostatin/GDF-8 protein (Recombinant) (His-Tag) (STJP019007)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Myostatin/GDF-8-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSTN |
| Gene ID | 2660 |
| Uniprot ID | GDF8_HUMAN |
| Accession Number | NP_005250 |
| Immunogen | Human |
| Immunogen Region | 267-375aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase. |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Protein Name | Growth/Differentiation Factor 8Gdf-8Myostatin |
| Database Links | Reactome: R-HSA-9617828 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Growth/Differentiation Factor 8 proteinGdf-8 proteinMyostatin proteinMSTN proteinGDF8 protein |
Information sourced from Uniprot.org