| Post Translational Modifications | N-terminus is methylated by METTL11A/NTM1. Phosphorylated by MYLK3 and MYLK2.promotes cardiac muscle contraction and function. Dephosphorylated by PPP1CB complexed to PPP1R12B. The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation).regulates cardiac torsion and workload distribution. |
| Function | Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion.as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force. During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly. |
| Protein Name | Myosin Regulatory Light Chain 2 - Ventricular/Cardiac Muscle IsoformMlc-2Mlc-2vCardiac Myosin Light Chain 2Myosin Light Chain 2 - Slow Skeletal/Ventricular Muscle IsoformMlc-2s/VVentricular Myosin Light Chain 2 |
| Database Links | Reactome: R-HSA-390522 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereA Band |
| Alternative Protein Names | Myosin Regulatory Light Chain 2 - Ventricular/Cardiac Muscle Isoform proteinMlc-2 proteinMlc-2v proteinCardiac Myosin Light Chain 2 proteinMyosin Light Chain 2 - Slow Skeletal/Ventricular Muscle Isoform proteinMlc-2s/V proteinVentricular Myosin Light Chain 2 proteinMYL2 proteinMLC2 protein |
Information sourced from Uniprot.org
