| Function | Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs. |
| Protein Name | Interferon-Induced Gtp-Binding Protein Mx1Interferon-Induced Protein P78Ifi-78kInterferon-Regulated Resistance Gtp-Binding Protein MxaMyxoma Resistance Protein 1Myxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionBinds Preferentially To Negatively Charged PhospholipidsColocalizes With Cchfv Protein N In The Perinuclear RegionIsoform 2: CytoplasmNucleusTranslocates Into The Nuclei Of Hsv-1 Infected Cells |
| Alternative Protein Names | Interferon-Induced Gtp-Binding Protein Mx1 proteinInterferon-Induced Protein P78 proteinIfi-78k proteinInterferon-Regulated Resistance Gtp-Binding Protein Mxa proteinMyxoma Resistance Protein 1 proteinMyxovirus Resistance Protein 1 Cleaved Into - Interferon-Induced Gtp-Binding Protein Mx1 - N-Terminally Processed proteinMX1 protein |
Information sourced from Uniprot.org
