Human MVP protein (Recombinant) (N-His) (STJP005411)

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STJP005411
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MVP-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: MVP
Gene ID: 9961
Uniprot ID: MVP_HUMAN
Immunogen Region: Ala2-Pro272
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11.
Function Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Protein Name Major Vault Protein
Mvp
Lung Resistance-Related Protein
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Nucleus
Nuclear Pore Complex
Perinuclear Region
5% Found In The Nuclear Pore Complex
Translocates From The Nucleus To The Cytoplasm Upon Egf Treatment
Alternative Protein Names Major Vault Protein protein
Mvp protein
Lung Resistance-Related Protein protein
MVP protein
LRP protein

Information sourced from Uniprot.org

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