| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response. Can mediate RIGI sumoylation and disrupt its polyubiquitination. |
| Protein Name | Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1E3 Sumo-Protein Ligase Mul1E3 Ubiquitin-Protein Ligase Mul1Growth Inhibition And Death E3 LigaseMitochondrial-Anchored Protein LigaseProtein HadesPutative Nf-Kappa-B-Activating Protein 266Ring Finger Protein 218Ring-Type E3 Ubiquitin Transferase Nfkb 1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinPeroxisomeTransported In Mitochondrion-Derived Vesicles From The Mitochondrion To The Peroxisome |
| Alternative Protein Names | Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1 proteinE3 Sumo-Protein Ligase Mul1 proteinE3 Ubiquitin-Protein Ligase Mul1 proteinGrowth Inhibition And Death E3 Ligase proteinMitochondrial-Anchored Protein Ligase proteinProtein Hades proteinPutative Nf-Kappa-B-Activating Protein 266 proteinRing Finger Protein 218 proteinRing-Type E3 Ubiquitin Transferase Nfkb 1 proteinMUL1 proteinC1orf166 proteinGIDE proteinMAPL proteinMULAN proteinRNF218 protein |
Information sourced from Uniprot.org
