| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human MUC-16/CA125-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Immunoreactivity: |
Loaded Human Mesothelin/MSLN Protein, C-hFc&His on ProA Biosensor, can bind Human CA125 Protein, C-His&Avi with an affinity constant of 17.2 nM as determined in BLI assay (Gator). |
| Gene Symbol: |
MUC16 |
| Gene ID: |
94025 |
| Uniprot ID: |
MUC16_HUMAN |
| Immunogen: |
Recombinant Human MUC-16/CA125 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly12660-Met12923) of human CA125/MUC16 (Accession #NP_078966.2) fused with a 6×His, Avi tag at the C-terminus. |
| Post Translational Modifications | Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| Protein Name | Mucin-16Muc-16Ovarian Cancer-Related Tumor Marker Ca125Ca-125Ovarian Carcinoma Antigen Ca125 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceMay Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain |
| Alternative Protein Names | Mucin-16 proteinMuc-16 proteinOvarian Cancer-Related Tumor Marker Ca125 proteinCa-125 proteinOvarian Carcinoma Antigen Ca125 proteinMUC16 proteinCA125 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
