| Function | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. |
| Protein Name | Microtubule-Associated Tumor Suppressor 1At2 Receptor-Binding ProteinAngiotensin-Ii Type 2 Receptor-Interacting ProteinMitochondrial Tumor Suppressor 1 |
| Cellular Localisation | MitochondrionGolgi ApparatusCell MembraneNucleusIn NeuronsTranslocates Into The Nucleus After Treatment With Angiotensin-IiIsoform 1: CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCytoplasmSpindleLocalizes With The Mitotic Spindle During Mitosis And With The Intercellular Bridge During Cytokinesis |
| Alternative Protein Names | Microtubule-Associated Tumor Suppressor 1 proteinAt2 Receptor-Binding Protein proteinAngiotensin-Ii Type 2 Receptor-Interacting Protein proteinMitochondrial Tumor Suppressor 1 proteinMTUS1 proteinATBP proteinATIP proteinGK1 proteinKIAA1288 proteinMTSG1 protein |
Information sourced from Uniprot.org
