Function | Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate. These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance. |
Protein Name | C-1-Tetrahydrofolate Synthase - CytoplasmicC1-Thf SynthaseEpididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase |
Database Links | Reactome: R-HSA-196757 |
Cellular Localisation | Cytoplasm |
Alternative Protein Names | C-1-Tetrahydrofolate Synthase - Cytoplasmic proteinC1-Thf Synthase proteinEpididymis Secretory Sperm Binding Protein Cleaved Into - C-1-Tetrahydrofolate Synthase - Cytoplasmic - N-Terminally Processed Includes - Methylenetetrahydrofolate Dehydrogenase - Methenyltetrahydrofolate Cyclohydrolase - Formyltetrahydrofolate Synthetase proteinMTHFD1 proteinMTHFC proteinMTHFD protein |
Information sourced from Uniprot.org