| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. |
| Function | High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit BetaFceriFc Epsilon Receptor I Beta-ChainIge Fc Receptor Subunit BetaMembrane-Spanning 4-Domains Subfamily A Member 2 |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | High Affinity Immunoglobulin Epsilon Receptor Subunit Beta proteinFceri proteinFc Epsilon Receptor I Beta-Chain proteinIge Fc Receptor Subunit Beta proteinMembrane-Spanning 4-Domains Subfamily A Member 2 proteinMS4A2 proteinAPY proteinFCER1B proteinIGER protein |
Information sourced from Uniprot.org
