| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). |
| Protein Name | C-Type Mannose Receptor 2C-Type Lectin Domain Family 13 Member EEndocytic Receptor 180Macrophage Mannose Receptor 2Urokinase-Type Plasminogen Activator Receptor-Associated ProteinUpar-Associated ProteinUrokinase Receptor-Associated ProteinCd Antigen Cd280 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative CLIA Names | C-Type Mannose Receptor 2 CLIA kitC-Type Lectin Domain Family 13 Member E CLIA kitEndocytic Receptor 180 CLIA kitMacrophage Mannose Receptor 2 CLIA kitUrokinase-Type Plasminogen Activator Receptor-Associated Protein CLIA kitUpar-Associated Protein CLIA kitUrokinase Receptor-Associated Protein CLIA kitCd Antigen Cd280 CLIA kitMRC2 CLIA kitCLEC13E CLIA kitENDO180 CLIA kitKIAA0709 CLIA kitUPARAP CLIA kit |
| Specificity | This kit recognizes Human MRC2 in samples. No significant cross-reactivity or interference between Human MRC2 and analogues was observed. |
| Reproducibility | Both intra-CV and inter-CV are |
Information sourced from Uniprot.org
| Item | Specifications | Storage |
| Micro CLIA Plate (Dismountable) | 96T: 8 wells ×12 strips strips | -20℃, 6 months |
| Reference Standard | 96T: 2 vials 48T: 1 vial | -20℃, 6 months |
| Concentrated Biotinylated Detection Ab (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃, 6 months |
| Concentrated HRP Conjugate (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃ (Protect from light), 6 months |
| Reference Standard & Sample Diluent | 1 vial, 20 mL | 2-8°C, 6 months |
| Biotinylated Detection Ab Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
| HRP Conjugate Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
| Concentrated Wash Buffer (25×) | 1 vial, 30 mL | 2-8°C, 6 months |
| Substrate Reagent A | 1 vial, 5 mL | 2-8℃ (Protect from light) |
| Substrate Reagent B | 1 vial, 5 mL | 2-8℃ (Protect from light) |
| Plate Sealer | 5 pieces | |
| Manual | 1 copy | |
| Certificate of Analysis | 1 copy | |
| Sample Type | Range (%) | Average Recovery (%) |
| Serum(n=8) | 93-105 | 99 |
| EDTA plasma(n=8) | 87-100 | 94 |
| Cell culture media(n=8) | 90-104 | 97 |
| | Intra-assay Precision | Intra-assay Precision | Intra-assay Precision | Inter-assay Precision | Inter-assay Precision | Inter-assay Precision |
| Sample | 1.00 | 2.00 | 3.00 | 1.00 | 2.00 | 3.00 |
| n | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 |
| Mean (pg/mL) | 207.98 | 480.52 | 1431.39 | 212.36 | 457.99 | 1359.01 |
| Standard deviation | 24.56 | 44.83 | 113.37 | 22.28 | 40.72 | 130.33 |
| CV (%) | 11.81 | 9.33 | 7.92 | 10.49 | 8.89 | 9.59 |
