Human MRAS protein (Recombinant) (N-His) (STJP016341)

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STJP016341
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Host: E.coli
Applications: ELISA/Immunogen/SDS-PAGE/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human MRAS-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: Please contact us for further information.
Gene Symbol: MRAS
Gene ID: 22808
Uniprot ID: RASM_HUMAN
Immunogen Region: Met1-Gln204
Immunogen: Homo sapiens (Human)
Function Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.
Protein Name Ras-Related Protein M-Ras
Ras-Related Protein R-Ras3
Database Links Reactome: R-HSA-5673000
Reactome: R-HSA-9726840
Reactome: R-HSA-9726842
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Alternative Protein Names Ras-Related Protein M-Ras protein
Ras-Related Protein R-Ras3 protein
MRAS protein
RRAS3 protein

Information sourced from Uniprot.org

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